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The entourage effect essentially refers to the interaction of not only primary and secondary therapeutic agents (e.g., alkaloids, pre- and postbiotics, antioxidants, and microbial communities living in fermented foods) shown to have therapeutic potential, but also myriad secondary metabolites in the nutritional dark matter in the foodome [448, 479, 590]

They also believed that vitamin B levels should be measured, yet if such measurements are impossible, alternative vitamin B treatment would play a major role in the treatment of patients